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RNA binding and translational suppression by bicoid

Nature volume 379, pages 746–749 (1996)Cite this article

Abstract

THE anterior determinant bicoid (bcd) of Drosophila is a homeo-domain protein. It forms an anterior-to-posterior gradient in the embryo and activates, in a concentration-dependent manner, several zygotic segmentation genes during blastoderm formation1–4. Its posterior counterpart, the homeodomain transcription factor caudal (cad)5–7, forms a concentration gradient in the opposite direction, emanating from evenly distributed messenger RNA in the egg. In embryos lacking bed activity as a result of mutation, the cad gradient fails to form and cad becomes evenly distributed throughout the embryo8. This suggests that bed may act in the region-specific control of cad mRNA translation. Here we report that bed binds through its homeodomain to cad mRNA in vitro, and exerts translational control through a bed-binding region of cad mRNA.

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References

  1. St Johnston, R. D. & Nüsslein-Volhard, C. Cell 68, 201–219 (1992).

    Article  CAS  Google Scholar 

  2. Pankratz, M. J. & Jäckle, H. in The Development of Drosophila melanogaster (eds Bate, M. & Martinez Arias, A.) 467–516 (Cold Spring Harbor Laboratory Press, NY, 1993).

    Google Scholar 

  3. Driever, W. & Nüsslein-Volhard, C. Cell 54, 83–93 (1988).

    Article  CAS  Google Scholar 

  4. Struhl, G., Struhl, K. & Macdonald, P. M. Cell 57, 1259–1263 (1989).

    Article  CAS  Google Scholar 

  5. Rivera-Pomar, R., Lu, X., Perrimon, N., Taubert, H. & Jäckle, H. Nature 376, 253–256 (1995).

    Article  ADS  CAS  Google Scholar 

  6. Mlodzik, M., Fjose, A. & Gehring. W. J. EMBO J. 4, 2961–2969 (1985).

    Article  CAS  Google Scholar 

  7. Macdonald, P. & Struhl, G. Nature 324, 537–545 (1986).

    Article  ADS  CAS  Google Scholar 

  8. Mlodzik, M. & Gehring, W. J. Development 101, 421–435 (1987).

    CAS  Google Scholar 

  9. Mlodzik, M. & Gehring, W. J. Cell 48, 465–478 (1987).

    Article  CAS  Google Scholar 

  10. Pieler, T. & Theunissen, O. Trends biocnem. Sci. 18, 226–230 (1993).

    Article  CAS  Google Scholar 

  11. Sauer, F. & Jäckle, H. Nature 353, 563–566 (1991).

    Article  ADS  CAS  Google Scholar 

  12. Driever, W. & Nüsslein-Volhard, C. Nature 337, 138–143 (1989).

    Article  ADS  CAS  Google Scholar 

  13. Ruden, D. & Jäckle, H. Development 121, 63–73 (1995).

    CAS  PubMed  Google Scholar 

  14. Sauer, F. & Jäckle, H. M. Nature 364, 454–457 (1993).

    Article  ADS  CAS  Google Scholar 

  15. Lehmann, R. & Nüsslein-Volhard, C. Nature 329, 167–170 (1987).

    Article  ADS  Google Scholar 

  16. Tautz, D. Nature 332, 281–284 (1988).

    Article  ADS  CAS  Google Scholar 

  17. Wharton, R. & Struhl, G. Cell 67, 955–967 (1991).

    Article  CAS  Google Scholar 

  18. Struhl, G. Nature 338, 741–744 (1989).

    Article  ADS  CAS  Google Scholar 

  19. Hülskamp, M., Schröder, C., Pfeifle, C., Jäckle, H. & Tautz, D. Nature 338, 629–632 ((1988).

    Article  ADS  Google Scholar 

  20. Murata, Y. & Wharton, R. Cell 80, 747–756 (1995).

    Article  CAS  Google Scholar 

  21. Berleth, T. et al. EMBO J. 7, 1749–1756 (1988).

    Article  CAS  Google Scholar 

  22. Driever, W. thesis, Eberhard-Karls-Univ. Tübingen (1989).

  23. Simpson-Brose, M., Treisman, J. & Desplan, C. Cell 78, 855–865 (1994).

    Article  CAS  Google Scholar 

  24. Tautz, D. & Pfeifle, C. Chromosoma 98, 81–85 (1989).

    Article  CAS  Google Scholar 

  25. Rebagliati, M. Cell 58, 231–232 (1989).

    Article  CAS  Google Scholar 

  26. Müller, M. et al. EMBO J. 7, 4299–4304 (1988).

    Article  Google Scholar 

  27. Hess, M. A. & Duncan, R. J. biol. Chem. 269, 10913–10922 (1994).

    CAS  PubMed  Google Scholar 

  28. Soeller, W., Poole, S. & Kornberg, T. Genes Dev. 2, 68–81 (1988).

    Article  CAS  Google Scholar 

  29. Kerrigan, L. A., Croston, G. E., Lira, L. M. & Kadonaga, J. T. J. biol. Chem. 266, 574–582 (1991).

    CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Abteilung Molekulare Entwicklungsbiologie, Max-Planck-lnstitut für biophysikalische Chemie, Am Fassberg, D-37077, Göttingen, Germany

    Rolando Rivera-Pomar, Dierk Niessing, Urs Schmidt-Ott & Herbert Jacklë

  2. Biozentrum der Universität Basel, Klingelbergstrasse 70, CH-4056, Basel, Switzerland

    Walter J. Gehring

Authors
  1. Rolando Rivera-Pomar
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  2. Dierk Niessing
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  3. Urs Schmidt-Ott
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  4. Walter J. Gehring
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  5. Herbert Jacklë
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Rivera-Pomar, R., Niessing, D., Schmidt-Ott, U. et al. RNA binding and translational suppression by bicoid. Nature 379, 746–749 (1996). https://doi.org/10.1038/379746a0

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