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Evidence for the presence and functioning of the spinal generator for ejaculation in the neonatal male rat

International Journal of Impotence Research volume 17, pages 270–276 (2005)Cite this article

Abstract

A spinal pattern generator controls ejaculation in the male rat. In the present study, the hypothesis that the spinal generator for ejaculation was functional at early postnatal stages was evaluated. To this purpose, the expression of the ejaculatory motor pattern and its pharmacological activation in spinally transected neonatal rats from postnatal day 2 to weaning were investigated. Results revealed the presence of the rhythmic ejaculatory motor pattern in neonatal male rats. As in adult sexually experienced animals, the neonatal ejaculatory motor pattern could be elicited after the application of an ejaculation-like-releasing stimulus. The rhythmic genital motor response of neonates exhibited a gradual maturation that was reflected in its motor parameters until showing the features of the adult response at postnatal day 28. Besides, the ejaculatory motor pattern could be induced by the systemic injection of oxytocin in 7-day-old neonates as well as in adult animals. Present findings provide evidence for the presence of the spinal generator for ejaculation early during postnatal development, suggesting that its organisation is innate.

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References

  1. Grillner S . Neurobiological bases of the rhythmic motor acts in vertebrates. Science 1985; 228: 143–149.

    Article  CAS  Google Scholar 

  2. Delcomyn F . Neural basis of rhythmic behavior in animals. Science 1980; 210: 492–498.

    Article  CAS  Google Scholar 

  3. Grillner S . The motor infrastructure: from ion channels to neuronal networks. Nat Rev 2003; 4: 573–586.

    Article  CAS  Google Scholar 

  4. Fenelon VS, Casasnovas B, Simmers J, Meyrand P . Development of rhythmic pattern generators. Curr Opin Neurobiol 1998; 8: 705–709.

    Article  CAS  Google Scholar 

  5. Arshavsky I . Cellular and network properties in the functioning of the nervous system: from central pattern generators to cognition. Brain Res Rev 2003; 41: 229–267.

    Article  Google Scholar 

  6. Carro-Juárez M, Cruz SL, Rodríguez-Manzo G . Evidence for the involvement of a spinal pattern generator in the control of the genital motor pattern of ejaculation. Brain Res 2003; 975: 222–228.

    Article  Google Scholar 

  7. Holmes GM, Chapple WD, Leipheimer RE, Sachs BD . Electromyographic analysis of the male rat perineal muscles during copulation and reflexive erections. Physiol Behav 1991; 49: 1235–1246.

    Article  CAS  Google Scholar 

  8. Sachs BD, Meisel RL . Pubertal development of penile reflexes and copulation in male rats. Psychoneuroendocrinology 1979; 4: 287–296.

    Article  CAS  Google Scholar 

  9. Meisel RL, Sachs BD . Spinal transection accelerates the developmental expression of penile reflexes in male rats. Physiol Behav 1980; 24: 289–292.

    Article  CAS  Google Scholar 

  10. Moore C, Dou H, Jaruska JM . Maternal stimulation affects the number of motor neurones in a sexually dimorphic nucleus of the lumbar cord. Brain Res 1992; 572: 52–56.

    Article  CAS  Google Scholar 

  11. Tribollet E et al. Early appearance and transiet expression of vasopressin receptors in the brain of rat fetus and infant. An autordiographic and electrophysiological study. Brain Res Dev Brain Res 1991; 58: 13–24.

    Article  CAS  Google Scholar 

  12. Reiter MK et al. Localization of oxytocin binding sites in the thoracic and upper lumbar spinal cord of the adult and postnatal rat: a histoautoradiographic study. Eur J Neurosci 1994; 6: 98–104.

    Article  CAS  Google Scholar 

  13. Liu X et al. Presence of functional vasopressin receptors in spinal ventral horn neurons of young rats: a morphological and electrophysiological study. Eur J Neuroci 2003; 17: 1833–1846.

    Article  CAS  Google Scholar 

  14. Pearson SA, Mouihate A, Pittman QJ, Whelan PJ . Peptidergic activation of locomotor pattern generators in the neonatal spinal cord. J Neuroci 2003; 23: 10154–10163.

    CAS  Google Scholar 

  15. Swanson LW, McKellar S . The distribution of oxytocin- and neurophysin-stained fibers in the spinal cord of the rat and monkey. J Comp Neurol 1979; 188: 87–106.

    Article  CAS  Google Scholar 

  16. Buijs RM . Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat. Pathways to the limbic system, medulla oblongata, and spinal cord. Cell Tissue Res 1978; 192: 423–435.

    Article  CAS  Google Scholar 

  17. Giuliano F et al. Spinal proerectile effect of oxytocin in anaesthetized rats. Am J Physiol 2001; 280: R1870–R1877.

    CAS  Google Scholar 

  18. Veronneau-Longueville F et al. Oxytocinergic innervation of autonomic nuclei controlling penile erection in the rat. Neuroscience 1999; 93: 1437–1447.

    Article  CAS  Google Scholar 

  19. Moose F et al. Release of oxytocin and vasopressin by magnocellular nuclei in vitro: specific facilitatory effect of oxytocin on its own release. J Endocrinol 1984; 102: 63–72.

    Article  Google Scholar 

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Authors and Affiliations

  1. Laboratorio de Comportamiento Reproductivo, Escuela de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Tlaxcala, Tlaxcala, Mexico

    M Carro-Juárez

  2. Departamento de Farmacobiología, Cinvestav, IPN, México, DF, Mexico

    G Rodríguez-Manzo

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  1. M Carro-Juárez
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  2. G Rodríguez-Manzo
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Correspondence to M Carro-Juárez.

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Carro-Juárez, M., Rodríguez-Manzo, G. Evidence for the presence and functioning of the spinal generator for ejaculation in the neonatal male rat. Int J Impot Res 17, 270–276 (2005). https://doi.org/10.1038/sj.ijir.3901305

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  • DOI: https://doi.org/10.1038/sj.ijir.3901305

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