Protein folding is vital to living organisms because it adds functional flesh to the bare bones of genes. But errors in this process generate misfolded structures that can be lethal.
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Ellis, R., Pinheiro, T. Danger — misfolding proteins. Nature 416, 483–484 (2002). https://doi.org/10.1038/416483a
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DOI: https://doi.org/10.1038/416483a