The NFAT transcription factors activate the expression of many genes involved in the immune response and the development of a variety of tissues. They have now been implicated in Down's syndrome.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Epstein, C. J. The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models (Cambridge Univ. Press, 1986).
Arron, J. R. et al. Nature 441, 595–600 (2006).
Gwack, Y. et al. Nature 441, 646–650 (2006).
Richtsmeier, J. T., Baxter, L. L. & Reeves, R. H. Dev. Dyn. 217, 137–145 (2000).
Amano, K. et al. Hum. Mol. Genet. 212, 1333–1340 (2004).
Belichenko, P. V. et al. J. Comp. Neurol. 480, 281–298 (2004).
Kleschevnikov, A. M. et al. J. Neurosci. 24, 8153–8160 (2004).
Cataldo, A. M. et al. J. Neurosci. 23, 6788–6792 (2003).
Branchi, I. et al. J. Neuropathol. Exp. Neurol. 63, 429–440 (2004).
Altafaj, X. et al. Hum. Mol. Genet. 10, 1915–1923 (2001).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Epstein, C. Critical genes in a critical region. Nature 441, 582–583 (2006). https://doi.org/10.1038/441582a
Published:
Issue Date:
DOI: https://doi.org/10.1038/441582a
This article is cited by
-
Advances in understanding the association between Down syndrome and Hirschsprung disease (DS–HSCR)
Pediatric Surgery International (2018)
-
Overexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity in an In Vitro Neuronal Model of Down Syndrome: Consequences on Cell Process Formation and Extension
Neurotoxicity Research (2016)
-
Using C. elegans to Decipher the Cellular and Molecular Mechanisms Underlying Neurodevelopmental Disorders
Molecular Neurobiology (2013)
-
Fasudil, a Rho-kinase inhibitor, protects against excessive endurance exercise training-induced cardiac hypertrophy, apoptosis and fibrosis in rats
European Journal of Applied Physiology (2012)
-
Down syndrome and the enteric nervous system
Pediatric Surgery International (2008)