Damaged or foreign DNA stimulates immune responses by inducing the production of interferon proteins. New evidence indicates that this response is mediated by a cytosolic DNA sensor known as DAI.
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References
Akira, S., Uematsu, S. & Takeuchi, O. Cell 124, 783–801 (2006).
Takaoka, A. et al. Nature 448, 501–505 (2007).
Rotem, Z., Cox, R. A. & Isaacs, A. Nature 197, 564–566 (1963).
Jensen, K. E., Neal, A. L., Owens, R. E. & Warren, J. Nature 200, 433–434 (1963).
Meylan, E., Tschopp, J. & Karin, M. Nature 442, 39–44 (2006).
Hochrein, H. et al. Proc. Natl Acad. Sci. USA 101, 11416–11421 (2004).
Stetson, D. B. & Medzhitov, R. Immunity 24, 93–103 (2006).
Ishii, K. J. et al. Nature Immunol. 7, 40–48 (2006).
Schwartz, T., Behlke, J., Lowenhaupt, K., Heinemann, U. & Rich, R. Nature Struct. Biol. 8, 761–765 (2001).
Ha, S. C. et al. Biochim. Biophys. Acta 1764, 320–323 (2006).
Okabe, Y., Kawane, K., Akira, S., Taniguchi, T. & Nagata, S. J. Exp. Med. 202, 1333–1339 (2005).
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Chi, H., Flavell, R. Sensing the enemy within. Nature 448, 423–424 (2007). https://doi.org/10.1038/448423a
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DOI: https://doi.org/10.1038/448423a