Abstract
Prostate cancer has a distinctly recognized pattern of metastases: multifocal and osteoblastic lesions involving the axial skeleton and non-calcified lymph nodes in the pelvic and lumbar aortic groups. Most adenocarcinomas are capable of producing macrocalcification. We report a case of prostate cancer with de novo calcified metastases to the liver and retroperitoneal lymph nodes mimicking the pattern usually seen in mucin-producing adenocarcinomas arising from the gastrointestinal tract. To our knowledge, this is the first such case to be reported in the literature. We propose a multifactorial mechanism that supports dystrophic calcification in this case. The knowledge of atypical presentation of metastatic disease can prevent diagnostic delay and prompt initiation of therapy.
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Ghosh, P., Santosa, A., Lin, G. et al. De novo calcification of liver and nodal metastases in prostate carcinoma. Prostate Cancer Prostatic Dis 9, 448–451 (2006). https://doi.org/10.1038/sj.pcan.4500875
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DOI: https://doi.org/10.1038/sj.pcan.4500875