Figure 2: Lineages are respected during axolotl limb regeneration.
Kragl et al.1 find that, with the exception of cells in the dermis, the dedifferentiated cells contributing to limb regeneration largely remain lineage restricted. Because the experiments were carried out in juveniles, in which the bones have not fully ossified, the fate of bone cells after amputation is unknown. Similarly, owing to the paucity of markers, the fate of connective-tissue fibroblasts contributing to limb regeneration remains undefined. The blue arrow indicates that cartilage cells can sometimes contribute to the dermis.
