Recognition of aberrant cell death is a crucial function of the immune system. It seems that one way in which immune cells identify damage is by sensing actin, an abundant intracellular protein.
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References
Rock, K. L., Lai, J. J. & Kono, H. Immunol. Rev. 243, 191–205 (2011).
Seong, S. Y. & Matzinger, P. Nature Rev. Immunol. 4, 469–478 (2004).
Ahrens, S. et al. Immunity 36, 635–645 (2012).
Zhang, J. G. et al. Immunity 36, 646–657 (2012).
Osorio, C. & Reis e Sousa, C. Immunity 34, 651–664 (2011).
Sancho, D. et al. J. Clin. Invest. 118, 2098–2110 (2008).
Huysamen, C. et al. J. Biol. Chem. 283, 16693–16701 (2008).
Caminschi, I. et al. Blood 112, 3264–3273 (2008).
Sancho, D. et al. Nature 458, 899–903 (2009).
Zelenay, S. et al. J. Clin. Invest. 122, 1615–1627 (2012).
Iborra, S. et al. J. Clin. Invest. 122, 1628–1643 (2012).
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Brown, G. Actin' dangerously. Nature 485, 589–590 (2012). https://doi.org/10.1038/485589a
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DOI: https://doi.org/10.1038/485589a
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Characterization of a small molecule modulator of inflammatory cytokine production
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