Table 2 Modeling the decay of disequilibrium with distance, estimated for autosomes, X-chromosome and four different genomic regions

From: Linkage disequilibrium in young genetically isolated Dutch population

 

No.

Model parameters (H1)

Variance explained

H 1 vs H 2

H 0 vs H 1

Region

D′ cp

H

T

(%)

P A

P B

P A

P B

Autosomes

11302

0.057 (0.05–0.067)

12 (10.5–13.9)

4.36

0.76

0.63

<0.0001 c

<1/2500

Autosomesa

104

0.069 (0.044–0.101)

15.8 (4.4–28.6)

5.72

0.9

0.56

0.014

0.004

X-chromosomesb

922

0.053 (0.028–0.090)

12.8 (5.1–28.1)

2.58

0.063

0.026 b

<0.0001

0.001

3p12

28

0.299 (0.160– 0.462)

200.8 (80.7–335)

39.3

0.73

0.38

0.0003

<1/2500

3p13

120

0.145 (0.043– 0.350)

63.8 (3.7–171.2)

8.16

0.23

0.11

0.002

0.015

10q26

66

0.241 (0.009– 1)

1015 (19–2292.3)

15.7

0.42

0.17

0.001

0.025

18p11

105

0.124 (0.032– 0.179)

289.5 (14.8–571.3)

7.07

0.12

0.1

0.006

0.001

  1. The number of D′cp values used is given in brackets. Parameter estimates (95% bootstrap confidence interval) and percent of variance explained for the accepted hypotheses and P-value coming from F-ratio test (PA) and bootstrap (PB) are shown. P-values less than 0.05 are in bold.
  2. aOnly adjacent marker pairs separated by at least 20 cM used.
  3. bParameters of H2 model are (H=0.06 (0.038–0.126), L=0.006 (0.000–0.011), T=19.4 (11.6–367.7)).
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