Table 1 Survival time of various mouse strains following intravenous infection with M. tuberculosis H37Rv

From: A new coding mutation in the Tnf-α leader sequence in tuberculosis-sensitive I/St mice causes higher secretion levels of soluble TNF-α

Mouse strain (H2 haplotype)

Mean survival time±s.e.m. (days)

A/Sn (H2a)

45.3±2.0

I/St (H2j)

23.5±1.4*

B10 (H2b)

54.3±3.7

B10.WB (H2j)

38.0±2.9**

B10.BR (H2k)

63.0±4.2

B10.D2 (H2d)

60.5±3.6

  1. M. tuberculosis suspensions were prepared and infections were carried out in 8–10 weeks old male and female mice as previously described.2
  2. Infection dose: 5 × 105 CFUs for A/Sn and I/St mice, and 106 CFUs for B10 and the H2-congenic mice on B10 background.
  3. *P<0.00001 compared to A/Sn strain;
  4. **P<0.01 compared to other B10 strains using unpaired two-tailed t-test.
  5. Data for A/Sn and I/St mice were published previously.2
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