Table 2 Frequencies of dominant CXCL12 genotypes and haplotypes with results from comparing these frequencies between seroconvertors (HIV+) and high-risk exposed uninfected participants (HIV−)

SNP	African Americans				European Americans
	HIV+	HIV−	OR (95% CI)	P	HIV+	HIV−	OR (95% CI)	P
	(n=294)	(n=81)			(n=668)	(n=145)
Dominant genotype frequencies
rs754618	0.193	0.173	1.15 (0.60–2.18)	0.76	0.543	0.441	1.50 (1.05–2.16)	0.03
rs17156287	0.082	0.077	1.07 (0.42–2.72)	1.00	0.168	0.140	1.25 (0.74–2.11)	0.45
ss46566436	—	—%	—	—	0.069	0.056	1.23 (0.54–2.79)	0.84
rs2839693	0.455	0.462	0.96 (0.59–1.60)	0.90	0.279	0.268	1.06 (0.70–1.60)	0.84
rs266085	0.409	0.449	0.85 (0.48–1.45)	0.61	0.585	0.674	0.68 (0.46–1.01)	0.06
rs2297630	0.107	0.082	1.33 (0.53–3.33)	0.67	0.467	0.401	1.30 (0.89–1.92)	0.21
rs1801157	0.125	0.148	0.82 (0.40–1.83)	0.58	0.376	0.490	0.63 (0.44–0.90)	0.01
rs1801157−	0.003	0.025	0.13 (0–2.56)	0.11	0.038	0.052	0.72 (0.31–1.86)	0.38
recessive^*
rs2522	0.160	0.187	0.83 (0.42–1.75)	0.60	0.064	0.052	1.25 (0.54–3.33)	0.70
rs1065297	0.217	0.205	1.08 (0.56–2.14)	0.88	0.066	0.054	1.23 (0.56–3.09)	0.72
Dominant haplotype frequencies
Haplotype I	0.532	0.553	0.93 (0.55–1.56)	0.79	0.357	0.420	0.77 (0.52–1.16)	0.21
Haplotype III	0.161	0.145	1.15 (0.56–2.38)	0.71	0.023	0.050	0.42 (0.16–1.16)	0.08
Haplotype VII	0.066	0.118	0.54 (0.23–1.26)	0.15	0.023	0.025	0.95 (0.26–3.40)	0.94

n is the number of individuals examined.
OR are odds ratios (95% confidence intervals).
P and OR values for SNPs obtained using FET, those for haplotypes using logistic regression.
^*Results for a recessive genetic model for rs1801157 are included to allow comparison with our earlier work.¹⁷ For this SNP only, 303 African American and 768 European American seroconvertors were studied.
% Blanks (—) indicate tests not conducted due to near-zero haplotype frequencies.

Search