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Estrogen receptor 2 and progesterone receptor gene polymorphisms and lipid levels in women with different hormonal status

The Pharmacogenomics Journal volume 5, pages 30–34 (2005)Cite this article

Abstract

Sex steroid hormones have multiple effects on lipid metabolism. We investigated the association between two common single nucleotide polymorphisms of the estrogen receptor 2 gene (ESR2), 1082G>A and 1730A>G, and PROGINS polymorphism of the progesterone receptor gene (PGR) with lipoprotein levels in a cross-sectional study with 472 women of European descent. The women were classified into three subgroups according to hormonal status, premenopausal women (n=187; mean age=34±9.7 years), postmenopausal women exposed to hormone replacement therapy (HRT) (n=118; 56±6.7 years) and postmenopausal women unexposed to HRT (n=167; 58±9.8 years). The premenopausal and postmenopausal women exposed to HRT, both carriers of G/A genotype, exhibited LDL-C (P=0.027 and 0.001, respectively) and T-chol levels (P=0.035 and 0.001, respectively) lower than carriers of G/G genotype. This association was not observed in postmenopausal women unexposed to HRT. These results suggest that ESR2 1082G>A genotype may influence LDL-C levels in women with abundant estrogen levels, due to either endogenous or exogenous sources.

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Abbreviations

BMI:

body mass index

CHD:

coronary heart disease

ERT:

estrogen replacement therapy

ESR1:

estrogen receptor 1

ESR2:

estrogen receptor 2

HDL-C:

high-density lipoprotein cholesterol

HERS:

Heart and Estrogen/Progestin Replacement Study

HRT:

hormone replacement therapy

LDL-C:

low-density lipoprotein cholesterol

PGR:

progesterone receptor

SD:

standard deviation

SNPs:

single nucleotide polymorphisms

T-chol:

total cholesterol

TG:

triglyceride

WHI:

Women's Health Initiative

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Acknowledgements

Thanks are due to Ana Lúcia S. Antunes and Maria Perpétua de O Pinto from the Laboratório de Análises Clínicas da Faculdade de Farmácia. We are also grateful to Fabiana M de Andrade, Fabiano Roldão Silveira, Marilu Fiegenbaum, Marcel Arsand and Vanessa S Mattevi for help in sample collection, and to Dr Sidia M Callegari-Jacques for her advice on the statistical analysis. Financial support was provided by Programa de Apoio a Núcleos de Excelência (PRONEX, Brazil) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil).

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Authors and Affiliations

  1. Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    S Almeida, N Franken, M R Zandoná & M H Hutz

  2. Departamento de Ginecologia e Obstetrícia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    M C Osório-Wender

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  1. S Almeida
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Correspondence to M H Hutz.

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Almeida, S., Franken, N., Zandoná, M. et al. Estrogen receptor 2 and progesterone receptor gene polymorphisms and lipid levels in women with different hormonal status. Pharmacogenomics J 5, 30–34 (2005). https://doi.org/10.1038/sj.tpj.6500272

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