Abstract
We examined DNA from 116 female and four male breast cancer patients for loss of heterozygosity (LOH). DNA was analysed by polymerase chain reaction using ten microsatellite markers on chromosome 11. Three distinct regions of LOH were identified: 11p15.5, 11q13 and 11q22-qter with a LOH frequency of 19, 23 and 37-43% respectively. The marker D11S969 showing the highest frequency of LOH (43%) is located at the 11q24.1-q25 region. No previous molecular genetic studies have shown frequent LOH at the region telomeric to q23 on chromosome 11. Southern analysis revealed that LOH at 11q13 was due to amplification, whereas LOH at 11q22qter was due to deletion. LOH at 11p15.5 was associated with paucity of hormone receptor proteins, high S-phase and positive node status. An association was found between LOH at 11q13 and positive node status. LOH at the 11q22-qter region correlated with a high S-phase fraction. A significant association was found between LOH at 11p15 and chromosome regions 17q21 (the BRCA1 region) and 3p.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 24 print issues and online access
$259.00 per year
only $10.79 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gudmundsson, J., Barkardottir, R., Eiriksdottir, G. et al. Loss of heterozygosity at chromosome 11 in breast cancer: association of prognostic factors with genetic alterations. Br J Cancer 72, 696–701 (1995). https://doi.org/10.1038/bjc.1995.396
Issue Date:
DOI: https://doi.org/10.1038/bjc.1995.396
This article is cited by
-
Polymorphisms in CARS are associated with gastric cancer risk: a two-stage case–control study in the Chinese population
Gastric Cancer (2017)
-
Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response
BMC Cancer (2014)
-
Differences and homologies of chromosomal alterations within and between breast cancer cell lines: a clustering analysis
Molecular Cytogenetics (2014)
-
The dual functions of YAP-1 to promote and inhibit cell growth in human malignancy
Cancer and Metastasis Reviews (2014)
-
Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer
Cellular Oncology (2013)