Figure 5
From: Loss of Myosin Vb in colorectal cancer is a strong prognostic factor for disease recurrence
RAB family members RAB8A and RAB25 are downregulated in CRC. (A) Dot plot showing the log2 expression intensities of different RAB genes in adenoma (beige) and CRC (blue) samples compared to unmatched healthy colorectal mucosa (grey) samples in a meta-analysis of different CRC data sets, including 829 patients. Bar represents the mean expression intensity (*P<0.05, ***P<0.001, t-test corrected for multiple testing). (B) ROC curves with corresponding AUC values for RAB genes when classifying CRC and healthy patients in the meta-analysis. Distribution of gene expression values for normal and CRC samples are shown in the insets. (C) RAB8A and RAB25 expression levels in bulk tissue of matched tumour (CRC, n=50) and non-tumour (normal, n=50) samples from CRC patients. Data are presented as mean±s.d.; *P<0.05, ***P<0.001, paired t-test.
