Abstract
The aim of this study was to evaluate taste perception, salivary flow rate and oral pathologies in three different groups of patients undergoing hematopoietic SCT (HSCT) classified according to time post transplant. Group I (n=20) up to 150 days after HSCT, group II (n=20) between 151 and 1095 days and group III (n=21) more than 1095 days. Taste acuity was measured by four basic tastes of four solutions, in three concentrations (M): NaCl, sucrose, citric acid and caffeine. Patients classified flavors as sweet, sour, salty, bitter and without flavor. The intensity was considered high, medium and low. Unstimulated saliva was collected and salivary flow rates (ml/min) were determined. Of 61 patients, 31 had chronic GVHD. For the sweet solution, the high and low concentrations represented a challenge for those patients. No patients were sensitive to the low concentration of caffeine solution (P=0.05). Saliva flow rate was diminished in 10 of 61 (16%) patients and hyposalivation was more intense in groups II/III (P=0.007). There was no correlation between taste dysfunction and oral chronic GVHD. The results indicated taste alterations only for the sweet and salty tastes even in patients up to 3 years after HSCT and may not correlate with oral chronic GVHD and with hyposalivation.
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References
Kim UK, Breslin PA, Reed D, Drayna D . Genetics of human taste perception. J Dent Res 2004; 83: 448–453.
Kinnamon SC, Margolskee RF . Mechanisms of taste transduction. Curr Opin Neurobiol 1996; 6: 506–513.
Berteretche MV, Dalix AM, d’Ornano AM, Bellisle F, Khayat D, Faurion A . Decreased taste sensitivity in cancer patients under chemotherapy. Support Care Cancer 2004; 12: 571–576.
Comeau TB, Epstein JB, Migas C . Taste and smell dysfunction in patients receiving chemotherapy: a review of current knowledge. Support Care Cancer 2001; 9: 575–580.
Sherry VW . Taste alterations among patients with cancer. Clin J Oncol Nurs 2002; 6: 73–77.
Wickham RS, Rehwaldt M, Kefer C, Shott S, Abbas K, Glynn-Tucker E et al. Taste changes experienced by patients receiving chemotherapy. Oncol Nurs Forum 1999; 26: 697–706.
Imanguli MM, Pavletic SZ, Guadagnini JP, Brahim JS, Atkinson JC . Chronic graft versus host disease of oral mucosa: review of available therapies. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101: 175–183.
Nakamura S, Hiroki A, Shinohara M, Gondo H, Ohyama Y, Mouri T et al. Oral involvement in chronic graft-versus-host disease after allogeneic bone marrow transplantation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996; 82: 556–563.
Nagler RM, Nagler A . The molecular basis of salivary gland involvement in graft-vs.-host disease. J Dent Res 2004; 83: 98–103.
Socie G, Salooja N, Cohen A, Rovelli A, Carreras E, Locasciulli A et al. Nonmalignant late effects after allogeneic stem cell transplantation. Blood 2003; 101: 3373–3385.
Avsar A, Elli M, Darka O, Pinarli G . Long-term effects of chemotherapy on caries formation, dental development, and salivary factors in childhood cancer survivors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007; 104: 781–789.
Schubert MM, Sullivan KM, Morton TH, Izutsu KT, Peterson DE, Flournoy N et al. Oral manifestations of chronic graft-v-host disease. Arch Intern Med 1984; 144: 1591–1595.
Hiroki A, Nakamura S, Shinohara M, Oka M . Significance of oral examination in chronic graft-versus-host disease. J Oral Pathol Med 1994; 23: 209–215.
Mattsson T, Arvidson K, Heimdahl A, Ljungman P, Dahllof G, Ringden O . Alterations in taste acuity associated with allogeneic bone marrow transplantation. J Oral Pathol Med 1992; 21: 33–37.
Flink H, Tegelberg A, Lagerlof F . Influence of the time of measurement of unstimulated human whole saliva on the diagnosis of hyposalivation. Arch Oral Biol 2005; 50: 553–559.
Marinone MG, Rizzoni D, Ferremi P, Rossi G, Izzi T, Brusotti C . Late taste disorders in bone marrow transplantation: clinical evaluation with taste solutions in autologous and allogeneic bone marrow recipients. Haematologica 1991; 76: 519–522.
Schiffman SS, Gatlin CA . Clinical physiology of taste and smell. Annu Rev Nutr 1993; 13: 405–436.
Ripamonti C, Fulfaro F . Taste alterations in cancer patients. J Pain Symptom Manage 1998; 16: 349–351.
Gallagher P, Tweedle DE . Taste threshold and acceptability of commercial diets in cancer patients. JPEN J Parenter Enteral Nutr 1983; 7: 361–363.
Ravasco P . Aspects of taste and compliance in patients with cancer. Eur J Oncol Nurs 2005; 9 (Suppl 2): S84–S91.
Epstein JB, Phillips N, Parry J, Epstein MS, Nevill T, Stevenson-Moore P . Quality of life, taste, olfactory and oral function following high-dose chemotherapy and allogeneic hematopoietic cell transplantation. Bone Marrow Transplant 2002; 30: 785–792.
Coracin FL, Pizzigatti Correa ME, Camargo EE, Peterson DE, de Oliveira Santos A, Vigorito AC et al. Major salivary gland damage in allogeneic hematopoietic progenitor cell transplantation assessed by scintigraphic methods. Bone Marrow Transplant 2006; 37: 955–959.
Rhodes VA, McDaniel RW, Hanson B, Markway E, Johnson M . Sensory perception of patients on selected antineoplastic chemotherapy protocols. Cancer Nurs 1994; 17: 45–51.
DeWys WD, Walters K . Abnormalities of taste sensation in cancer patients. Cancer 1975; 36: 1888–1896.
Murray SM, Pindoria S . Nutrition support for bone marrow transplant patients. Cochrane Database Syst Rev 2009; 5: Art no. CD002920.
Deeg HJ, Seidel K, Bruemmer B, Pepe MS, Appelbaum FR . Impact of patient weight on non-relapse mortality after marrow transplantation. Bone Marrow Transplant 1995; 15: 461–468.
Acknowledgements
This work was supported for grant by the Sao Paulo State Research Support Foundation—FAPESP (proc no. 2008/1857). The authors thank Ms Raquel Suzana Foglio for English review.
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Boer, C., Correa, M., Miranda, E. et al. Taste disorders and oral evaluation in patients undergoing allogeneic hematopoietic SCT. Bone Marrow Transplant 45, 705–711 (2010). https://doi.org/10.1038/bmt.2009.237
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DOI: https://doi.org/10.1038/bmt.2009.237
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