Table 2 Univariate analysis

From: Impact of pre-transplant diffusion lung capacity for nitric oxide (DLNO) and of DLNO/pre-transplant diffusion lung capacity for carbon monoxide (DLNO/DLCO) ratio on pulmonary outcomes in adults receiving allogeneic stem cell transplantation for hematological diseases

 

NRM

PRM

Severe pulmonary complication a

ARDS

 

%

P-value

%

P-value

%

P-value

%

P-value

DRI: low risk+intermediate vs high risk+very−high risk

14.4 (7.4–23.4) vs 9.4 (2.3–22.6)

0.25

5.8 (1.8–13.1) vs 3.1 (0.2–14.2)

0.56

25.9 (16.2–36.7) vs 25.0 (11.5–41.1)

0.55

10.1 (4.4–18.5) vs 3.1 (0.2–14.2)

0.16

Disease: lymphoid vs myeloid

19.8 (8.6–34.4) vs 9.0 (3.6–17.3)

0.04

11.4 (3.5–24.4) vs 1.5 (0.1–7.2)

0.02

39.7 (23.5–55.5) vs 17.9 (9.8–28.0)

0.03

14.2 (5.1–27.8) vs 4.5 (1.2–11.4)

0.04

HCT-CI: 0 vs ⩾1

8.3 (2.1–20.2) vs 15.2 (7.7–24.9)

0.14

0.0 (0.0–0.0) vs 7.6 (2.8–15.6)

0.09

21.7 (10.0–36.3) vs 27.3 (17.1–38.4)

0.39

2.7 (0.2–12.3) vs 10.6 (4.6–19.5)

0.11

Previous pulmonary event: no vs yes

9.4 (3.8–18.1) vs 18.4 (8.0–32.4)

0.5

3.1 (0.6–9.8) vs 7.9 (2.0–19.4)

0.28

21.8 (12.6–32.6) vs 31.6 (17.5–46.7)

0.28

3.1 (0.06–0.09) vs 15.8 (6.3–29.2)

<0.01

Age: < vs ⩾ median (58 years)

15.6 (7.2–26.9) vs 9.8 (3.6–19.9)

0.57

3.9 (0.7–12.0) vs 5.9 (1.5–14.8)

0.65

26.8 (15.5–39.3) vs 24.0 (13.2–36.6)

0.94

7.6 (2.4–16.8) vs 8.0 (2.5–17.7)

0.76

Conditioning regimen: RIC vs MAC

10.7 (5.2–18.4) vs 22.2 (6.6–43.6)

0.11

5.9 (2.2–12.5) vs 0.0 (0.0–0.0)

0.29

24.9 (16.2–34.6) vs 278 (9.6–49.6)

0.97

5.9 (2.2–12.5) vs 16.7 (3.9–37.2)

0.18

Use of ATG: yes vs no

9.5 (4.4–16.9) vs 27.8 (9.7–49.5)

0.12

3.6 (0.9–9.3) vs 11.1 (1.7–30.5)

0.18

23.7 (15.2–33.2) vs 33.3 (13.0–55.3)

0.52

5.9 (2.2–12.4) vs 16.7 (3.9–37.3)

0.18

LFS: 2 vs ⩾3

12.7 (5.1–23.9) vs 12.7 (5.5–23.0)

0.79

4.3 (0.8–13.0) vs 5.5 (1.4–13.8)

0.76

19 (9.3–31.3) vs 30.9 (0.2–0.4)

0.06

6.4 (1.6–15.8) vs 9.1 (3.3–18.5)

0.40

DLCO10s % of predicted normal value: >80% vs 60–80% vs <60%

12.7 (5.1–23.9) vs 12.8 (5.1–24.1) vs 12.5 (0.4–45.3)

0.95

4.3 (0.8–13.0) vs 4.3 (0.8– 13.0) vs 12.5 (0.4–45.3)

0.57

19.0 (9.3–31.3) vs 27.7 (15.7–41.0) vs 50.0 (12.2–79.6)

0.06

6.4 (1.6–15.8) vs 6.4 (1.6–15.9) vs 25.0 (3.0–57.9)

0.20

DLNO % of predicted normal value: >80% vs 60–80% vs <60%

18.2 (8.4–30.9) vs 8.0 (2.5–17.7) vs 11.1 (0.5–40.9)

0.26

9.1 (2.8–19.9) vs 0.0 (0.0–0.0) vs 11.1 (0.5–40.9)

0.07

20.5 (10.0–33.5) vs 24.0 (13.2–36.6) vs 59.3 (13.0–87.4)

0.02

9.1 (2.8–19.9) vs 2.0 (0.2–9.3) vs 35.6 (5.7–68.8)

<0.005

 

HR

P-value

HR

P-value

HR

P-value

HR

P-value

DLCO10s % of predicted normal valueb

1.0 (1.0–1.1)

0.94

1.0 (0.9–1.0)

0.23

1.0 (0.9–1.0)

0.04

1.0 (0.9–1.0)

0.13

DLNO % of predicted normal valueb

1.0 (0.9–1.0)

0.35

1.0 (0.9–1.1)

0.45

2.0 (1.1–3.7)

0.02

1.0 (0.9–1.0)

0.17

DLNO/DLCO ratiob

0.9 (0.5–1.6)

0.7

1.6 (1.0–2.6)

0.04

0.9 (0.5–1.7)

0.78

1.6 (0.6–4.0)

0.34

  1. Abbreviations: ARDS=acute respiratory distress syndrome; ATG=antithymocyte globulin; DLCO=diffusion capacity for carbon monoxide (with correction for hemoglobin concentration); DLNO=diffusion capacity for nitric oxide; DRI=disease risk index;15 LFS=lung function score;13 MAC=myeloablative conditioning; NRM=cumulative incidence of non-relapse mortality; PRM=cumulative incidence of pulmonary related mortality; RIC=reduced intensity regimen.
  2. aDefined by complication requiring hospitalization.
  3. bAnalysis considering continuous variables.
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