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Outcomes in hepatitis C virus seropositive lymphoma and myeloma patients after autologous stem cell transplantation

Bone Marrow Transplantation volume 51, pages 999–1001 (2016)Cite this article

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Hematopoietic stem cell transplantation (HSCT) is the cornerstone therapy for many hematological disorders. Advances in HSCT with better supportive care and earlier referral for HSCT have led to an increase in the number of patients undergoing HSCT. However, the post-HSCT period is often accompanied by infections and complications involving the liver, the lungs and the hematopoietic system.

The prevalence of hepatitis C virus (HCV) in cancer patients varies with different cancers, ranging from 1.4 to 32%.1, 2, 3 Overall in the pre-HSCT patient population with hematological malignancies, the prevalence of HCV is around 6%.3

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References

  1. Kang J, Cho JH, Suh CW, Lee DH, Oh HB, Sohn YH et al. High prevalence of hepatitis B and hepatitis C virus infections in Korean patients with hematopoietic malignancies. Ann Hematol 2011; 90: 159–164.

    Article  Google Scholar 

  2. Ferri C, Caracciolo F, Zignego AL, La Civita L, Monti M, Longombardo G et al. Hepatitis C virus infection in patients with non-Hodgkin’s lymphoma. Br J Haematol 1994; 88: 392–394.

    Article  CAS  Google Scholar 

  3. Locasciulli A, Testa M, Valsecchi MG, Bacigalupo A, Solinas S, Tomas JF et al. The role of hepatitis C and B virus infections as risk factors for severe liver complications following allogeneic BMT: a prospective study by the Infectious Disease Working Party of the European Blood and Marrow Transplantation Group. Transplantation 1999; 68: 1486–1491.

    Article  CAS  Google Scholar 

  4. Mahale P, Kontoyiannis DP, Chemaly RF, Jiang Y, Hwang JP, Davila M et al. Acute exacerbation and reactivation of chronic hepatitis C virus infection in cancer patients. J Hepatol 2012; 57 (6): 1177–1185.

    Article  Google Scholar 

  5. Locasciulli A, Bruno B, Alessandrino EP, Meloni G, Arcese W, Bandini G et al. Hepatitis reactivation and liver failure in haemopoietic stem cell transplants for hepatitis B virus (HBV)/hepatitis C virus (HCV) positive recipients: a retrospective study by the Italian group for blood and marrow transplantation. Bone Marrow Transplant 2003; 31: 295–300.

    Article  CAS  Google Scholar 

  6. Strasser SI, Myerson D, Spurgeon CL, Sullivan KM, Storer B, Schoch HG et al. Hepatitis C virus infection and bone marrow transplantation: a cohort study with 10-year follow-up. Hepatology 1999; 29: 1893–1899.

    Article  CAS  Google Scholar 

  7. Ramos CA, Saliba RM, de Padua L, Khorshid O, Shpall EJ, Giralt S et al. Impact of hepatitis C virus seropositivity on survival after allogeneic hematopoietic stem cell transplantation for hematologic malignancies. Haematologica 2009; 94: 249–257.

    Article  Google Scholar 

  8. Ozdogan O, Ratip S, Ahdab YA, Dane F, Ahdab HA, Imeryuz N et al. Causes and risk factors for liver injury following bone marrow transplantation. J Clin Gastroenterol 2003; 36: 421–426.

    Article  Google Scholar 

  9. Lindsay KL . Introduction to therapy of hepatitis C. Hepatology 2002; 36: S114–S120.

    PubMed  Google Scholar 

  10. Bjorkstrand B . European Group for Blood and Marrow Transplantation Registry studies in multiple myeloma. Semin Hematol 2001; 38: 219–225.

    Article  CAS  Google Scholar 

  11. Child JA, Morgan GJ, Davies FE, Owen RG, Bell SE, Hawkins K et al. High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma. N Engl J Med 2003; 348: 1875–1883.

    Article  CAS  Google Scholar 

  12. Gisselbrecht C, Glass B, Mounier N, Singh Gill D, Linch DC, Trneny M et al. Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era. J Clin Oncol 2010; 28: 4184–4190.

    Article  Google Scholar 

  13. Nieto Y, Popat U, Anderlini P, Valdez B, Andersson B, Liu P et al. Autologous stem cell transplantation for refractory or poor-risk relapsed Hodgkin’s lymphoma: effect of the specific high-dose chemotherapy regimen on outcome. Biol Blood Marrow Transplant 2013; 19: 410–417.

    Article  CAS  Google Scholar 

  14. Khouri IF, Saliba RM, Hosing C, Okoroji G-J, Acholonu S, Anderlini P et al. Concurrent administration of high-dose rituximab before and after autologous stem-cell transplantation for relapsed aggressive B-cell non-Hodgkin’s lymphomas. J Clin Oncol 2005; 23: 2240–2247.

    Article  CAS  Google Scholar 

  15. Sperotto A, Silvestri F, Fanin R, Damiani D, Geromin A, Cerno M et al. Feasibility of autologous stem cell transplantation in chronic carriers of hepatitis B and hepatitis C virus. Leuk Lymphoma 2000; 36: 323–330.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Hematology–Oncology, Baylor College of Medicine, Houston, TX, USA

    A Varma

  2. Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    A Varma, R M Saliba, A Afrough, C Hosing, I F Khouri, Y Nieto, N D Shah, S Parmar, Q Bashir, S Ahmed, R B Jones, P Kebriaei, A L Olson, E J Shpall, A M Alousi, M H Qazilbash, R E Champlin & U Popat

  3. Department of Infectious Diseases, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    H A Torres

Authors
  1. A Varma
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  2. R M Saliba
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  3. H A Torres
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  5. C Hosing
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  11. S Ahmed
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  13. P Kebriaei
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  14. A L Olson
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  15. E J Shpall
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  16. A M Alousi
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  17. M H Qazilbash
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  18. R E Champlin
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  19. U Popat
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Corresponding author

Correspondence to U Popat.

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The authors declare no conflict of interest.

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Varma, A., Saliba, R., Torres, H. et al. Outcomes in hepatitis C virus seropositive lymphoma and myeloma patients after autologous stem cell transplantation. Bone Marrow Transplant 51, 999–1001 (2016). https://doi.org/10.1038/bmt.2016.28

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  • DOI: https://doi.org/10.1038/bmt.2016.28

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