Figure 6

Chromatin remodeling in genes associated with effector function. (A) Distribution of H3K27me3 and H3K4me3 modifications at canonical effector-associated genes—T-box 21 (Tbx21), PR domain containing 1 with ZNF domain (Prdm1), perforin 1 (Prf1), granzyme B (Gzmb), and interferon gamma (Ifng)—in the following antigen-experienced CD8⁺ T-cell subsets: naïve (T_N), stem cell memory (T_SCM), central memory (T_CM), and effector memory (T_EM). (B) Graph shows normalized tag density of H3K4me3 and H3K27me3 (chromatin remodeling) and RMA-normalized intensity (gene expression) for indicated genes and CD8⁺ T-cell subsets.