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Machine-learning model makes predictions about network biology

A deep-learning model called Geneformer has been developed and pretrained using about 30 million single-cell gene-expression profiles to enable it to make predictions about gene-network biology in instances in which gene-expression data are limited. Geneformer can be tuned for many downstream applications to accelerate discovery of key gene-network regulators and candidate therapeutic targets.

This is a summary of: Theodoris, C. V. et al. Transfer learning enables predictions in network biology. Nature https://doi.org/10.1038/s41586-023-06139-9 (2023).

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doi: https://doi.org/10.1038/d41586-023-01504-0

‘Expert opinion’ is published under a CC BY 4.0 licence.

References

  1. Vaswani, A. et al. in Proc. 31st Conference on Neural Information Processing Systems (eds Guyon, I. et al.) 6000–6010 (NIPS, 2017).

    Google Scholar 

  2. Devlin, J. et al. in Proc. Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies Vol. 1 (eds Burstein, J. et al.) 4171–4186 (Assoc. Comput. Linguistics, 2019).

    Google Scholar 

  3. He, K. et al. in Proc. IEEE Computer Society Conference on Computer Vision and Pattern Recognition 770–778 (IEEE, 2016).

    Google Scholar 

  4. Theodoris, C. V. et al. Cell 160, 1072–1086 (2015).

    Article  PubMed  Google Scholar 

  5. Theodoris, C. V. et al. Science 371, eabd0724 (2021).

    Article  PubMed  Google Scholar 

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