Figure 3

CanSeq variant review and return decision process. The variant review and return decision process is compared when performed by a tumor board (a) and a protocol-driven approach (b). The cumulative number of the incoming curated variants over time is shown in dark red. The cumulative number of variants that have received a return decision over time is shown in light red. The efficiency of return decision was calculated as a function of cumulative incoming curated variants to cumulative variants with reporting decisions over the same period of time. The somatic and germ-line rules for the protocol-based return decision algorithm are shown (c).