Abstract
The wild-type baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) infects a range of mammalian cell types in vitro but does not replicate in these cells. The current study investigated the in vivo effect of AcMNPV in the mouse model of liver cirrhosis induced by the mutagen dimethylnitrosamine. Intraperitoneal injection of AcMNPV induced an immune response. The baculovirus was taken up by the liver and spleen where it suppressed liver injury and fibrosis through the induction of interferons. This study presents the first evidence of the feasibility of using baculovirus to treat liver cirrhosis.
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Acknowledgements
This work was supported, in part, by a grant from the Research and Development Program for New Bio-industry Initiatives and by a Grant-in-Aid for High Technology Research, no. 09309011, from the Ministry of Education, Science, Sports, and Culture, Japan.
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Nishibe, Y., Kaneko, H., Suzuki, H. et al. Baculovirus-mediated interferon alleviates dimethylnitrosamine-induced liver cirrhosis symptoms in a murine model. Gene Ther 15, 990–997 (2008). https://doi.org/10.1038/gt.2008.29
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DOI: https://doi.org/10.1038/gt.2008.29
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