Table 2 Comparison of clinical parameters and humoral factors before and after 6 months of combination treatment

From: Comparison of combination therapies, including the angiotensin receptor blocker olmesartan and either a calcium channel blocker or a thiazide diuretic, in elderly patients with hypertension

 

CCB combination

Diuretic combination

Parameters

Before

6 months

Before

6 months

Total cholesterol (mg per 100 ml)

210±46

191±34*

222±38

203±34*

Triglycerides (mg per 100 ml)

120±62

113±64

114±55

126±65

HDL-cholesterol (mg per 100 ml)

49±13

51±13

54±12

49±12**

Fasting blood sugar (mg per 100 ml)

87±8

89±11

95±12

97±13

Serum potassium (mEq l−1)

4.07±0.46

4.09±0.34

4.11±0.44

4.18±0.32

Serum creatinine (mg per 100 ml)

0.90±0.28

0.87±0.23

0.79±0.20

0.85±0.25*

eGFR (ml min−1 per 1.73 m2)

60.2±13.8

62.0±14.1

68.5±14.3

64.0±14.5*

Urinary albumin/creatinine ratio (mg g−1)

83.3±220.2

43.6±67.5

41.0±52.4

16.3±26.3**

Serum uric acid (mg per 100 ml)

5.65±1.46

5.65±1.31

5.20±1.63

5.54±1.36

PRA (ng ml−1 per h)

1.19±1.6

2.29±3.36*

1.21±0.66

2.42±2.50*

Plasma aldosterone (pg ml−1)

92±49

72±34*

92±47

68±26*

BNP (pg ml−1)

32.7±33.0

35.8±26.4

42.7±45.9

60.8±123.2

  1. Abbreviations: BNP, brain natriuretic peptide; CCB, calcium channel blocker; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; PRA, plasma renin activity.
  2. *P<0.05, **P<0.01, vs. values before combination treatment.
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