Abstract
Background:
Overweight and obesity in early life tends to track into later life. Not much is known about tracking of abdominal fat. Our objective was to examine the extent of tracking of abdominal fat measures during the first six years of life.
Design:
We performed a prospective cohort study among 393 Dutch children followed from the age of 2 years (90% range 1.9; 2.3) until the age of 6 years (90% range 5.7; 6.2). At both ages, we performed abdominal ultrasound to measure abdominal subcutaneous and preperitoneal fat distances and areas, and we calculated the preperitoneal/subcutaneous fat distance ratio. High abdominal fat measures were defined as values in the upper 15%.
Results:
Abdominal subcutaneous fat distance and area, and preperitoneal fat area at 2 years were correlated with their corresponding measures at 6 years (all P-values <0.01), with the strongest coefficients for abdominal subcutaneous fat measures. Preperitoneal fat distance at the age of 2 years was not correlated with the corresponding measure at 6 years. The tracking coefficient for preperitoneal/subcutaneous fat distance ratio from 2 to 6 years was r=0.36 (P<0.01). Children with high abdominal subcutaneous fat measures at 2 years had increased risk of having high abdominal subcutaneous fat measures at 6 years (odds ratios 9.2 (95% confidence interval (CI) 4.1–20.8) and 12.4 (95% CI 5.4–28.6) for subcutaneous fat distance and area, respectively). These associations were not observed for preperitoneal fat measures.
Conclusions:
Our findings suggest that both abdominal subcutaneous and preperitoneal fat mass measures track during childhood, but with stronger tracking for abdominal subcutaneous fat measures. An adverse abdominal fat distribution in early life may have long-term consequences.
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Acknowledgements
The Generation R Study is conducted by the Erasmus MC in close collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam, the Municipal Health Service Rotterdam area, Rotterdam, the Rotterdam Homecare Foundation, Rotterdam and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (STAR), Rotterdam. We gratefully acknowledge the contribution of participating mothers, general practitioners, hospitals, midwives and pharmacies in Rotterdam. This work was supported by the Erasmus MC, Rotterdam, the Erasmus University Rotterdam and by the Netherlands Organization for Health Research and Development and the Netherlands Organization for Health Research and Development. This research also received funding from the European Union’s Seventh Framework Programme (FP7/2007–2013), project EarlyNutrition under grant agreement no. 289346 and an unrestricted grant from Nutricia Research. VWVJ received an additional grant from the Netherlands Organization for Health Research and Development (VIDI 016.136.361) and an European Research Council Consolidator Grant (ERC-2014-CoG-648916).
Author contributions
SV, OG and VWVJ designed and conducted the research and wrote the paper. SV analysed the data. OG, JFF, EMB, MAB, AH and RG provided comments and consultation regarding the analyses, interpretation of the results and manuscript. SV and VWVJ had primary responsibility for final content. All authors gave final approval of the version to be published.
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Vogelezang, S., Gishti, O., Felix, J. et al. Tracking of abdominal subcutaneous and preperitoneal fat mass during childhood. The Generation R Study. Int J Obes 40, 595–600 (2016). https://doi.org/10.1038/ijo.2015.252
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DOI: https://doi.org/10.1038/ijo.2015.252
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