Table 3 Changes in glucose metabolism due to inactivity stratified by low-GI and high-GI SSB

	Low-GI			High-GI			Difference between changes due to inactivity ^a	Difference between inactivity periods ^b
	Activity	Inactivity	Δinactivity−activity	Activity	Inactivity	Δinactivity−activity
Glucose metabolism
CGM_tAUC (mg dl⁻¹ × 24 h)	2379±172	2339±178	−41±194	2278±103	2450±136	171±160^**	<0.01	0.04
24-h c-peptide (μg per day)	40.6±20.7	45.0±15.1	4.4±15.1	41.7±18.3	64.8±24.3	23.1±22.5^**	<0.05	<0.01
Glucose_fasting (mmol l⁻¹)	3.90±0.99	4.14±0.74	0.24±0.72	3.96±1.13	4.21±0.97	0.25±0.47	NS	NS
Insulin_fasting (mU l⁻¹)	4.75±2.31	5.95±2.45	1.20±2.06	5.17±2.12	7.10±3.30	1.93±1.80^**	NS	0.04
HOMA-IR	0.82±0.42	1.19±0.67	0.37±0.52*	0.70±0.45	1.55±1.20	0.85±0.86^**	0.04	NS
Matsuda-ISI	14.5±5.9	9.4±3.4	−5.1±5.5**	17.5±8.0	7.8±3.6	-9.6±5.1^***	<0.01	NS
Glucose_tAUC-meal (mmol l⁻¹ per 3h)	13.3±3.0	12.5±3.0	−0.8±2.5	12.6±3.0	11.9±3.4	-0.7±1.5	NS	NS
Insulin_tAUC-meal (mU l⁻¹ per 3h)	31.4±7.0	38.6±9.6	7.2±8.1**	43.2±9.8	53.7±18.9	10.5±15.0*	NS	<0.01
Macronutrient oxidation
npRQ_fasting	0.78±0.04	0.84±0.05	0.06±0.04***	0.77±0.04	0.84±0.05	0.07±0.05^**	NS	NS
npRQ_tAUC-meal (per 3h)	2.49±0.14	2.64±0.16	0.15±0.10***	2.41±0.11	2.67±0.18	0.26±0.11^***	<0.01	NS

Abbreviations: CGM, continuous glucose measurement; NS, not significant; tAUC, total area under the curve; HOMA_IR, homeostasis model assessment of insulin resistance; Matsuda_ISI, Matsuda insulin sensitivity index; npRQ_tAUC-meal, area under the npRQ-curve during meal test (37 g isomaltulose versus 28 g maltodextrin+9 g sucrose).
Changes upon inactivity (Δinactive−active), paired t-test, *P<0.05, **P<0.01, ***P<0.001.
^aDifference between changes due to inactivity with low-GI and high-GI SSB, paired t-test.
^bDifference between low-GI and high-GI intervention after 1 week of physical inactivity, paired t-test.

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