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Glomerular filtration rate is related to dipping pattern in ambulatory blood pressure monitoring—a cross-sectional population-based study

Journal of Human Hypertension volume 24, pages 247–253 (2010)Cite this article

Abstract

A non-dipping pattern in ambulatory blood pressure monitoring (ABPM) increases the risk of cardiovascular disease. The association between renal function and the dipping pattern has not been studied in a random middle-aged population. This is a cross-sectional population-based study of 226 males and 234 females aged 40 to 62 years. Renal function was assessed with estimated glomerular filtration rate (eGFR). Non-dipping status was defined as a reduction of <10% between the daytime and the nighttime systolic BP. Non-dippers represented 18.7% of the study population. Their mean eGFR was 79.1 (s.d. 15.7) ml min–1 per 1.73 m2 as compared with a mean eGFR of 84.1 (s.d. 16.2) ml min–1 per 1.73 m2 in dippers (P=0.005); this difference remained significant after adjustments. Subjects in the lowest and in the middle eGFR tertiles had an independently increased risk of non-dipping in comparison with those in the highest eGFR tertile (odd ratios (OR), 2.34 (95% confidence interval (CI), 1.18 to 4.63) and OR, 2.01 (95% CI, 1.06 to 3.83), respectively). This study showed that even a minor deterioration in renal function is associated with increased risk of non-dipping pattern in ABPM in a random middle-aged population.

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Acknowledgements

The skillful technical assistance of Ms Saija Kortetjärvi, Ms Liisa Mannermaa, Ms Sirpa Rannikko and Ms Leena Ukkola is greatly appreciated. This work was supported by Research Council for Health of the Academy of Finland, the Finnish Foundation for Cardiovascular Research and the Finnish Kidney Foundation. The authors’ work was independent of the funders.

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  1. H Kastarinen and R-L Vasunta: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Internal Medicine and Biocenter Oulu, Institute of Clinical Medicine, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland

    H Kastarinen, R-L Vasunta, O Ukkola & Y A Kesäniemi

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  1. H Kastarinen
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Correspondence to H Kastarinen.

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Kastarinen, H., Vasunta, RL., Ukkola, O. et al. Glomerular filtration rate is related to dipping pattern in ambulatory blood pressure monitoring—a cross-sectional population-based study. J Hum Hypertens 24, 247–253 (2010). https://doi.org/10.1038/jhh.2009.66

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