Abstract
Objective:
To measure systemic haptoglobin (HPT) concentrations from birth in preterm (PT) and T newborns. To compare HPT in newborns without hemolysis or infection with values in bacteremic newborns.
Study Design:
HPT was measured using enzyme-linked immunosorbent assay in 30 PT and 28 T newborns without hemolysis or infection at birth (cord blood), on days of life 2 to 4, and at 1 to 2 weeks of life. Concentrations were measured in eight additional newborns with bacteremia. Wilcoxon–Mann–Whitney test was used for comparisons.
Result:
HPT concentrations were consistently measurable from birth in PT and T neonates. Values were significantly greater in 2- to 4-day-old PT and T newborns than in newborns at birth (P<0.01). Bacteremic newborns had higher HPT concentrations than newborns without infection (P=0.033).
Conclusion:
HPT is detectable from birth in PT and T newborns. HPT concentrations increase in bacteremic newborns. HPT levels may have clinical utility in the evaluation of neonatal sepsis.
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Acknowledgements
We thank Dr Kris Sekar for his thoughtful review and valuable comments to this manuscript, and Chee Yoon S Bauer for technical assistance with laboratory assays. We gratefully acknowledge the support of the Children's Medical Research Institute.
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Chavez-Bueno, S., Beasley, J., Goldbeck, J. et al. ‘Haptoglobin concentrations in preterm and term newborns’. J Perinatol 31, 500–503 (2011). https://doi.org/10.1038/jp.2010.197
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DOI: https://doi.org/10.1038/jp.2010.197
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