Table 2 Known recurrent alterations detected in 203 patients

From: Large but not small copy-number alterations correlate to high-risk genomic aberrations and survival in chronic lymphocytic leukemia: a high-resolution genomic screening of newly diagnosed patients

 

del(11q)

del(13q)

del(17p)

trisomy 12

Total number

27

110

9

23

Frequency (%)

13

54

4

11

Number and frequency (%) according to

Hierarchal model

27 (13)

96 (47)

9 (4)

18 (9)

Size range (Mbp)

9.6–55

0.44–76.8

0.98-whole p-arm

—

Start-stop range (Mbp)

74.6–134.2

29.3–114

whole p-arm

—

Average size (Mbp)

29.5

4.6

—

—

CDR

0.68 Mbp

33.5 kbp

0.98 Mbp

—

Average number of

    

CNAs/sample

    

All CNAs

3.6

2

7.3

2.7

CNAs <1 Mbp

0.96

0.7

1.2

0.9

CNAs 1–5 Mbp

0.7

0.78

1.5

0.22

CNAs >5 Mbp

1.96

0.27

4.4

1.6

  1. Abbreviation: CDR, common deleted region.
  2. 53 samples did not carry any of the known recurrent alterations.
Back to article page