Table 2 CD38 expression and IGHV gene mutational status in cases assigned to the +12,+19 subgroup (‘+12+19’) to cases exhibiting trisomy 12 yet without coexisting trisomy 19 (‘+12 non +19’) and cases negative for trisomy 12 (‘no +12’)

From: Coexistence of trisomies of chromosomes 12 and 19 in chronic lymphocytic leukemia occurs exclusively in the rare IgG-positive variant

 

‘+12+19’

‘+12 non +19’

‘No +12’

P-value

CD38+ cells>30%

16/19, 84.2%

136/241, 56.4%

111/561, 19.8%

<0.001

Median % of CD38+ cells

95

72.5

55

<0.05a

IGHV gene identity to germline ⩾98%

2/20, 10%

115/218, 52.7%

203/593, 34.2%

<0.001

IGHV gene identity to germline 100%

0/20, 0%

94/218, 43.1%

145/593, 24.5%

<0.001

  1. t-test: P=0.37 for comparison of ‘+12+19’ versus ‘12 isolated’; P=0.04 for comparison of subgroups ‘+12+19’ versus ‘no 12’; P=0.001 for comparison of subgroups ‘12 isolated’ versus ‘no 12’.
Back to article page