This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Immunosenescence and lymphomagenesis
Immunity & Ageing Open Access 21 September 2018
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Bilousova G, Marusyk A, Porter CC, Cardiff RD, DeGregori J . Impaired DNA replication within progenitor cell pools promotes leukemogenesis. PLoS Biol 2005; 3: e401.
Marusyk A, Porter CC, Zaberezhnyy V, DeGregori J . Irradiation selects for p53-deficient hematopoietic progenitors. PLoS Biol 2010; 8: e1000324.
Super HJ, McCabe NR, Thirman MJ, Larson RA, Le Beau MM, Pedersen-Bjergaard J et al. Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomerase II. Blood 1993; 82: 3705–3711.
Schmiegelow K, Al-Modhwahi I, Andersen MK, Behrendtz M, Forestier E, Hasle H et al. Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study. Blood 2009; 113: 6077–6084.
Corral J, Lavenir I, Impey H, Warren AJ, Forster A, Larson TA et al. An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes. Cell 1996; 85: 853–861.
Hooper M, Hardy K, Handyside A, Hunter S, Monk M . HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells. Nature 1987; 326: 292–295.
Mombaerts P, Clarke AR, Rudnicki MA, Iacomini J, Itohara S, Lafaille JJ et al. Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages. Nature 1992; 360: 225–231.
Wiederschain D, Kawai H, Shilatifard A, Yuan ZM . Multiple mixed lineage leukemia (MLL) fusion proteins suppress p53-mediated response to DNA damage. J Biol Chem 2005; 280: 24315–24321.
Acknowledgements
This work was supported by grants from the Brent Eley Foundation (CP), the Cancer League of Colorado (CP), The National Institutes of Health (P20 CA103680-CP; RO1 CA109657-JD) and the Leukemia and Lymphoma Society (108692-JD). MLL-AF9+ and HPRTmt mice were kindly provided by Drs JH Kersey and HA Jinnah, respectively.
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Additional information
Supplementary Information accompanies the paper on the Leukemia website
Rights and permissions
About this article
Cite this article
Porter, C., Baturin, D., Choudhary, R. et al. Relative fitness of hematopoietic progenitors influences leukemia progression. Leukemia 25, 891–895 (2011). https://doi.org/10.1038/leu.2011.22
Published:
Issue Date:
DOI: https://doi.org/10.1038/leu.2011.22
This article is cited by
-
Immunosenescence and lymphomagenesis
Immunity & Ageing (2018)
-
The Biology of Aging and Lymphoma: a Complex Interplay
Current Oncology Reports (2015)
-
Cell competition is a tumour suppressor mechanism in the thymus
Nature (2014)
-
DNA damage checkpoints in stem cells, ageing and cancer
Nature Reviews Molecular Cell Biology (2012)