This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Mesenchymal stromal cells promote the drug resistance of gastrointestinal stromal tumors by activating the PI3K-AKT pathway via TGF-β2
Journal of Translational Medicine Open Access 25 March 2023
-
Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells
Nature Communications Open Access 04 December 2020
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Pollard JA, Alonzo TA, Gerbing RB, Ho PA, Zeng R, Ravindranath Y et al. Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML. Blood 2010; 115: 2372–2379.
Tabe Y, Konopleva M . Advances in understanding the leukaemia microenvironment. Br J Haematol 2014; 164: 767–778.
Weisberg E, Barrett R, Liu Q, Stone R, Gray N, Griffin JD . FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML. Drug Resist Updat 2009; 12: 81–89.
Beghini A, Bellini M, Magnani I, Colapietro P, Cairoli R, Morra E et al. STI 571 inhibition effect on KITAsn822Lys-mediated signal transduction cascade. Exp Hematol 2005; 33: 682–688.
Mpakou VE, Kontsioti F, Papageorgiou S, Spathis A, Kottaridi C, Girkas K et al. Dasatinib inhibits proliferation and induces apoptosis in the KASUMI-1 cell line bearing the t(8;21)(q22;q22) and the N822K c-kit mutation. Leuk Res 2013; 37: 175–182.
Lennartsson J, Rönnstrand L . Stem cell factor receptor/c-Kit: from basic science to clinical implications. Physiol Rev 2012; 92: 1619–1649.
Watari K, Asano S, Shirafuji N, Kodo H, Ozawa K, Takaku F et al. Serum granulocyte colony-stimulating factor levels in healthy volunteers and patients with various disorders as estimated by enzyme immunoassay. Blood 1989; 73: 117–122.
Cairo MS, Suen Y, Sender L, Gillan ER, Ho W, Plunkett JM et al. Circulating granulocyte colony-stimulating factor (G-CSF) levels after allogeneic and autologous bone marrow transplantation: endogenous G-CSF production correlates with myeloid engraftment. Blood 1992; 79: 1869–1873.
Kawakami M, Tsutsumi H, Kumakawa T, Abe H, Hirai M, Kurosawa S et al. Levels of serum granulocyte colony-stimulating factor in patients with infections. Blood 1990; 76: 1962–1964.
Butterfield JH, Weiler DA, Hunt LW, Wynn SR, Roche PC . Purification of tryptase from a human mast cell line. J Leukoc Biol 1990; 47: 409–419.
Watari K, Ozawa K, Tajika K, Tojo A, Tani K, Kamachi S et al. Production of human granulocyte colony stimulating factor by various kinds of stromal cells in vitro detected by enzyme immunoassay and in situ hybridization. Stem Cells 1994; 12: 416–423.
Speck NA, Gilliland DG . Core-binding factors in haematopoiesis and leukaemia. Nat Rev Cancer 2002; 2: 502–513.
Wang Y-Y, Zhou G-B, Yin T, Chen B, Shi J-Y, Liang W-X et al. AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec. Proc Natl Acad Sci USA 2005; 102: 1104–1109.
Wang Y-Y, Zhao L-J, Wu C-F, Liu P, Shi L, Liang Y et al. C-KIT mutation cooperates with full-length AML1-ETO to induce acute myeloid leukemia in mice. Proc Natl Acad Sci USA 2011; 108: 2450–2455.
Acknowledgements
We thank Drs Stegmaier and Butterfield for kindly providing the SKNO-1 and HMC1.1 cells lines, respectively. We also thank Maria Suarez and Natasha Rossi for administrative assistance and members of the Williams laboratory for helpful discussions and suggestions. PMG is supported by NIH Grant 5K08CA154782-02. DAW is supported by 5R01DK062757, 5R01CA113969-08 and the William Lawrence and Blanche Hughes Foundation.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Additional information
Supplementary Information accompanies this paper on the Leukemia website
Supplementary information
Rights and permissions
About this article
Cite this article
Gordon, P., Dias, S. & Williams, D. Cytokines secreted by bone marrow stromal cells protect c-KIT mutant AML cells from c-KIT inhibitor-induced apoptosis. Leukemia 28, 2257–2260 (2014). https://doi.org/10.1038/leu.2014.212
Published:
Issue Date:
DOI: https://doi.org/10.1038/leu.2014.212
This article is cited by
-
Mesenchymal stromal cells promote the drug resistance of gastrointestinal stromal tumors by activating the PI3K-AKT pathway via TGF-β2
Journal of Translational Medicine (2023)
-
The bone marrow niche regulates redox and energy balance in MLL::AF9 leukemia stem cells
Leukemia (2022)
-
Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells
Nature Communications (2020)