Single-molecule studies reveal that a ring-like enzyme that encircles and 'slides' along one strand of duplex DNA, separating it from the other strand, overcomes molecular barriers in its path by transiently opening its ring. See Article p.205
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Notes
*This article and the paper under discussion1 were published online on 28 November 2012.
References
Yardimci, H. et al. Nature 492, 205–209 (2012).
Fu, Y. V. et al. Cell 146, 931–941 (2011).
Tanner, N. A. et al. Nature Struct. Mol. Biol. 15, 170–176 (2008).
Manosas, M., Spiering, M. M., Zhuang, Z., Benkovic, S. J. & Croquette, V. Nature Chem. Biol. 5, 904–912 (2009).
Hamdan, S. M., Loparo, J. J., Takahashi, M., Richardson, C. C. & van Oijen, A. M. Nature 457, 336–339 (2009).
Gai, D., Zhao, R., Li, D., Finkielstein, C. V. & Chen, X. S. Cell 119, 47–60 (2004).
Gomez-Lorenzo, M. G. et al. EMBO J. 22, 6205–6213 (2003).
Wessel, R., Schweizer, J. & Stahl, H. J. Virol. 66, 804–815 (1992).
Bochman, M. L. & Schwacha, A. Nucleic Acids Res. 38, 6078–6088 (2010).
Graham, B. W., Schauer, G. D., Leuba, S. H. & Trakselis, M. A. Nucleic Acids Res. 39, 6585–6595 (2011).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Trakselis, M., Graham, B. Molecular hurdles cleared with ease. Nature 492, 195–197 (2012). https://doi.org/10.1038/nature11758
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature11758