The secreted enzyme Notum has been found to inhibit the Wnt signalling pathway through removal of a lipid that is linked to the Wnt protein and that is required for activation of Wnt receptor proteins. See Article p.187
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Nusse, R. Disarming Wnt. Nature 519, 163–164 (2015). https://doi.org/10.1038/nature14208
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DOI: https://doi.org/10.1038/nature14208
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