Extended Data Figure 4: Hippocampal basal synaptic transmission and short-term synaptic plasticity are normal in MECP2-TG mice.
From: Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides
a, Long-term potentiation was induced by applying high-frequency stimulation to the Schaffer collateral axons, and field excitatory postsynaptic potentials (fEPSPs) were recorded at the Schaffer collateral-CA1 synapses of the hippocampus (stratum radiatum). b, MeCP2 overexpression did not affect Schaffer collateral basal synaptic transmission, as determined by the correlation between the slopes of the evoked fEPSPs and the amplitudes of the fibre volleys. c, d, MeCP2 overexpression did not affect short-term synaptic plasticity, as determined by paired-pulse facilitation (n = 7 for Flox group; n = 6 for Flox;TG group; n = 7 for Flox;TG;Cre-vehicle group; n = 7 for Flox;TG;Cre-TMX group). Data are mean ± s.e.m.
