Abstract
Inflammation underlies many chronic and degenerative diseases, but it also mitigates infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link inflammation to damage repair and regeneration in mammals are conserved in lower organisms, indicating that it is an evolutionarily important process. Recent insights have shed light on the cellular and molecular processes through which conventional inflammatory cytokines and Wnt factors control mammalian tissue repair and regeneration. This is particularly important for regeneration in the gastrointestinal system, especially for intestine and liver tissues in which aberrant and deregulated repair results in severe pathologies.
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Acknowledgements
The authors thank H. Gehart for producing the figures. Owing to space limitations, primary findings have been cited through reviews. Work by M.K., who is an American Cancer Society Research Professor and holder of the Ben and Wanda Hildyard Chair for Mitochondrial and Metabolic Diseases, is supported by the US National Institutes of Health, the Alliance for Lupus Research, the Lymphoma and Leukemia Society and the Superfund Basic Research Program. H.C. is supported by Stand Up to Cancer, the European Research Council, Alpe d'HuZes/KWF and the Netherlands Research Council NWO.
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Karin, M., Clevers, H. Reparative inflammation takes charge of tissue regeneration. Nature 529, 307–315 (2016). https://doi.org/10.1038/nature17039
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DOI: https://doi.org/10.1038/nature17039
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