Extended Data Figure 7: ACSS2 chromatin association and H3K9ac in dorsal hippocampus corresponds to H3K27ac and CBP enrichment in neuronal tissue.
From: Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory
a, Genome-wide compartment analysis of in vivo hippocampal ChIP–seq of H3K9ac and mouse forebrain H3K9ac ChIP–seq from ENCODE, showing a similar peak distribution genome-wide: although they originate in different brain regions, the in vivo H3K9ac ChIP data are in strong agreement (Spearman R = 0.67). b, Overlap of RefSeq transcripts targeted by the indicated enzyme or modification (peaks for CBP (GSM1629373) and H3K27ac (GSM1629397) in mouse cortical neurons were called using MACS2 (narrow peaks, FDR 0.1%) with an input sonication efficiency control (GSM1629381); peaks were associated to the nearest TSS among all RefSeq transcripts). c, Gene Ontology enrichment analysis performed on common CBP–ACSS2 targets, indicating that these enzymes co-target genes that modulate synapse biology and synaptic membrane potential.
