Molecules that block the activity or production of the protein ANGPTL3 have now been found to lower blood levels of lipoproteins and cholesterol in mice and healthy humans, mimicking the protective effects of genetic mutations in ANGPTL3.
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References
Stone, N. J. et al. Circulation 129, S1–S45 (2014).
Dewey, F. E. et al. N. Engl. J. Med. 377, 211–221 (2017).
Graham, M. J. et al. N. Engl. J. Med. 377, 222–232 (2017).
Musunuru, K. & Kathiresan, S. Circ. Res. 118, 579–585 (2016).
Goldstein, J. L. & Brown, M. S. Cell 161, 161–172 (2015).
Harper, A. R., Nayee, S. & Topol, E. J. Nature Rev. Genet. 16, 689–701 (2015).
Abifadel, M. et al. Nature Genet. 34, 154–156 (2003).
Cohen, J. C., Boerwinkle, E., Mosley, T. H. Jr & Hobbs, H. H. N. Engl. J. Med. 354, 1264–1272 (2006).
Zhao, Z. et al. Am. J. Hum. Genet. 79, 514–523 (2006).
Sabatine, M. S. et al. N. Engl. J. Med. 376, 1713–1722 (2017).
Koishi, R. et al. Nature Genet. 30, 151–157 (2002).
Shimizugawa, T. et al. J. Biol. Chem. 277, 33742–33748 (2002).
Musunuru, K. et al. N. Engl. J. Med. 363, 2220–2227 (2010).
Stitziel, N. O. et al. J. Am. Coll. Cardiol. 69, 2054–2063 (2017).
Khera, A. V. & Kathiresan, S. Nature Rev. Genet. 18, 331–344 (2017).
Kazi, D. S. et al. J. Am. Med. Assoc. 316, 743–753 (2016).
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Kathiresan, S. Putative medicines that mimic mutations. Nature 548, 530–531 (2017). https://doi.org/10.1038/nature23544
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DOI: https://doi.org/10.1038/nature23544