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Biological synthesis unbounded?

Nature Biotechnology volume 33, pages 1148–1149 (2015)Cite this article

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Chemical synthesis of specialty and commodity products still reigns supreme but greener, metabolic engineering approaches are gaining ground.

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Figure 1: A decision tree for designing a high-throughput screen for detecting a metabolic product.

References

  1. Galanie, S., Thodey, K., Trenchard, I.J., Filsinger Interrante, M. & Smolke, C.D. Science 349, 1095–1100 (2015).

    Article  CAS  Google Scholar 

  2. Thodey, K., Galanie, S. & Smolke, C.D. Nat. Chem. Biol. 10, 837–844 (2014).

    Article  CAS  Google Scholar 

  3. DeLoache, W.C. et al. Nat. Chem. Biol. 11, 465–471 (2015).

    Article  CAS  Google Scholar 

  4. Fossati, E., Narcross, L., Ekins, A., Falgueyret, J.P. & Martin, V.J. PLoS One 10, e0124459 (2015).

    Article  Google Scholar 

  5. Ehrenberg, R. Nature 521, 267–268 (2015).

    Article  CAS  Google Scholar 

  6. Yim, H. et al. Nat. Chem. Biol. 7, 445–452 (2011).

    Article  CAS  Google Scholar 

  7. Alper, H. & Stephanopoulos, G. Nat. Rev. Microbiol. 7, 715–723 (2009).

    Article  CAS  Google Scholar 

  8. Hsu, P.D., Lander, E.S. & Zhang, F. Cell 157, 1262–1278 (2014).

    Article  CAS  Google Scholar 

  9. National Rearch Council. Industrialization of Biology: A Roadmap to Accelerate the Advanced Manufacturing of Chemicals. http://www.nap.edu/catalog/19001/industrialization-of-biology-a-roadmap-to-accelerate-the-advanced-manufacturing (National Academies Press, 2015).

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Authors and Affiliations

  1. Brian F. Pfleger is at the University of Wisconsin-Madison, Madison, Wisconsin, USA,

    Brian F Pfleger

  2. Kristala L.J. Prather is in the Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.,

    Kristala L J Prather

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  1. Brian F Pfleger
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  2. Kristala L J Prather
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Correspondence to Brian F Pfleger or Kristala L J Prather.

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The authors declare no competing financial interests.

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Pfleger, B., Prather, K. Biological synthesis unbounded?. Nat Biotechnol 33, 1148–1149 (2015). https://doi.org/10.1038/nbt.3399

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