Supplementary Figure 11: Simplified schematic of synaptic connections in the straitum
From: Labeling and identifying cell-specific proteomes in the mouse brain
The striatum contains an equal number of glia and neurons. Of the neurons the majority are Medium spiny neurons (MSNs), the remainder are interneurons; most of the interneurons are GABAergic. The Neurotransmitters produced by each type of cell (GABA, DOPA or Glutamic acid are indicated). The primary targets of SORT tagging are coloured red. Glutamatergic neurons from the Prefronatal cortex (PFC), Hippocampus, thalamus (THAL) and Amgdyla (AYG) synapse onto MSNs in the striatum. Dopaminergic neurons from the Substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) synapse onto MSNs. Axons from MSNs synapse onto neurons in the Globus pallidus external (GPE), and Globus pallidus internal (Gpi)/ Substantia nigra (SNr)1. Reference: Yaeger et al. The ins and outs of the striatum: role in drug addiction. Neuroscience 301:539-541 (215)
