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Taming ricin toxin

Nature Biotechnology volume 21, pages 372–374 (2003)Cite this article

An immunotoxin is made safer by the introduction of a point mutation.

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Figure 1: The recombinant A chain of ricin toxin is missing the B domain needed to bind to cells, but can be directed to kill cancer cells by connecting it to a monoclonal antibody that binds to a tumor antigen.

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Authors and Affiliations

  1. chief of the Division of Cancer Biology, Clinical Immunotherapy Section, Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, 20892-4255, MD

    Robert J. Kreitman

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  1. Robert J. Kreitman
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Kreitman, R. Taming ricin toxin. Nat Biotechnol 21, 372–374 (2003). https://doi.org/10.1038/nbt0403-372

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