Abstract
Injection of recombinant chicken or bovine growth hormone into juvenile coho salmon (Oncorhynchus kisutch) resulted in significant dose dependent increases in growth rate and also improved feed conversion. Weight gain in fish receiving 5 μg/g/week recombinant chicken or bovine growth hormone intraperitoneally, over a 42 day period, was approximately twice that in untreated or saline injected control fish, while weight gain in fish receiving 1 μg/g/week was less, but still significantly greater than in controls. Specific growth rates ranged from 1.48 to 1.58 percent/day in control groups to 2.36 to 2.38 percent/day in fish treated with 5 μg/g/week recombinant growth hormone. The growth of salmon receiving recombinant growth hormones compared favourably with growth of those receiving similar doses of natural bovine growth hormone.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
ICLARM. 1982. International Centre for Living Aquatic Resources Management. Progress Report 1981–1982. 67 pp.
Higgs, D.A., Fagerlund, U.H.M., Eales, J.G. and McBride, J.R. 1982. Application of thyroid and steroid hormones as anabolic agents in fish culture. Comp. Biochem. Physiol. 73B: 143–176.
Higgs, D.A., Donaldson, E.M., Dye, H.M. and McBride, J.R. 1975. A preliminary investigation of the effects of bovine growth hormone on growth and muscle composition of coho salmon (Oncorhynchus kisutch). Gen. Comp. Endocrinol. 27: 240–253.
Higgs, D.A., Donaldson, E.M., Dye, H.M. and McBride, J.R. 1976. Influence of bovine growth hormone and L-thyroxine on growth, muscle composition and histological structure of the gonads, thyroid, pancreas and pituitary of coho salmon (Oncorhynchus kisutch). J. Fish. Res. Board Can. 33: 1585–1603.
Donaldson, E.M., Fagerlund, U.H.M., Higgs, D.A. and McBride, J.R. 1979. Hormonal enhancement of growth in fish, 455–597. In: Fish Physiology, Vol. VII, Chapter 9. Hoar, W. S., Randall, D. J., and Brett, J. R., (eds.), Academic Press, New York.
Markert, J.R., Higgs, D.A., Dye, H.M. and MacQuarrie, D.W. 1977. Influence of bovine growth hormone on growth rate, appetite and food conversion of yearling coho salmon (Oncorhynchus kisutch) fed two diets of different compositon. Can. J. Zool. 55: 74–83.
Higgs, D.A., Fagerlund, U.H.M., McBride, J.R., Dye, H.M. and Donaldson, E.M. 1977. Influence of combinations of bovine growth hormone, 17α-methyltestosterone and L-thyroxine on growth of yearling coho salmon (Oncorhynchus kisutch). Can J. Zool. 55: 1048–1056.
Higgs, D.A., Donaldson, E.M., McBride, J.R. and Dye, H.M. 1978. Evaluation of the potential for using a chinook salmon (Oncorhynchus tshawytscha) pituitary extract versus bovine growth hormone to enhance the growth of coho salmon (Oncorhynchus kisutch). Can J. Zool. 56: 1226–1231.
Souza, L.M., Boone, T.C., Murdock, D., Langley, K., Wypych, J., Fenton, D., Johnson, S., Lai, P.H., Everett, R., Hsu, R.-Y. and Bosselman, B. 1984. The application of recombinant DNA technologies to studies on chicken growth hormone. J. Exp. Zool. 232: 465–473.
Bewley, T.A. and Li, C.H. 1972. Molecular weight and circular dichroism studies of bovine and ovine pituitary growth hormones. Biochemistry. 11: 927–931.
Li, C.H. 1982. Human growth hormone: 1974–1981. Mol. Cell. Biochem. 46: 31–41.
Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82: 70–77.
Wallis, M. 1973. The primary structure of bovine growth hormone. FEBS Lett. 35: 11–14.
Santome, J.A., Dellacha, J.M., Paladini, A.C., Pena, C., Bioscoglio, N.J., Daurat, S.T., Poskus, E. and Wolfenstein, C.E.M. 1973. Primary structure of bovine growth hormone. Eur. J. Biochem. 37: 164–170.
Bliss, C.I. 1952. The Statistics of Bioassay. Academic Press, New York and London.
Steiny, S., King, D., Nishioka, R., Schilling, P.W. and Nicoll, C.S. 1984. Partial primary structure of coho salmon growth hormone (sGH). Abstracts 7th International Congress of Endocrinology, July 1–7, 1984, Quebec City, Canada. Excerpta Medica, International Congress Series 652, 1261.
Bilton, H.T., Alderdice, D.F. and Schnute, J.T. 1982. Influence of time and size at release of juvenile coho salmon on returns at maturity. Can. J. Fish. Aquat. Sci. 39: 426–447.
Vanstone, W.E. and Markert, J.R. 1968. Some morphological and biochemical changes in coho salmon Oncorhynchus kisutch, during parrsmolt transformation. J. Fish. Res. Board Can. 25: 2403–2418.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gill, J., Sumpter, J., Donaldson, E. et al. Recombinant Chicken and Bovine Growth Hormones Accelerate Growth in Aquacultured Juvenile Pacific Salmon Oncorhynchus kisutch. Nat Biotechnol 3, 643–646 (1985). https://doi.org/10.1038/nbt0785-643
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/nbt0785-643