The interior of the eukaryotic cell nucleus is populated by a multitude of microscopic domains termed nuclear bodies. Despite having attracted much attention, how these compartments form and are maintained remained elusive. Now, two live-cell imaging studies provide compelling evidence that nascent RNAs can act as transiently immobilized scaffolds that recruit specific nuclear body proteins.
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Carmo-Fonseca, M., Rino, J. RNA seeds nuclear bodies. Nat Cell Biol 13, 110–112 (2011). https://doi.org/10.1038/ncb0211-110
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DOI: https://doi.org/10.1038/ncb0211-110
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