The proto-oncogenic transcription factor c-Myc is a central regulator of the cell cycle and cell growth. Amino-terminal phosphorylation of c-Myc results in its proteasomal degradation. A new study shows that its dephosphorylation is regulated by the Pin1 prolyl isomerase and PP2A phosphatase, and that stabilized c-Myc can replace SV40 small T antigen in the oncogenic transformation of human cells.
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References
Pelengaris, S., Khan, M. & Evan, G. Nature Rev. Cancer 2, 764–776 (2002).
Dalla-Favera, R. et al. Proc. Natl Acad. Sci. USA 79, 7824–7827 (1982).
Dalla-Favera, R., Wong-Staal, F. & Gallo, R.C. Nature 299, 61–65 (1982).
Bhatia, K. et al. Nature Genet. 5, 56–61 (1993).
Gregory, M.A. & Hann, S.R. Mol. Cell. Biol. 20, 2423–2435 (2000).
Pulverer, B.J. et al. Oncogene 9, 59–70 (1994).
Yeh, et al. Nature Cell Biol. 6, 308–318 (2004).
Sears, R. et al. Genes Dev. 14, 2501–2514 (2000).
Janssens, V. and Goris, J. Biochem. J. 353, 417–439 (2001).
Lu, K.P., Liou, Y.C. & Zhou, X.Z. Trends Cell Biol. 12, 164–172 (2002).
Ryo, A., Liou, Y.C., Lu, K.P. & Wulf, G. J. Cell Sci. 116, 773–783 (2003).
Chen, W. et al. Cancer Cell 5, 127–136 (2004).
Shen, M., Stukenberg, P.T., Kirschner, M.W. & Lu, K.P. Genes Dev. 12, 706–720 (1998).
Matsuo, T. et al. Science 302, 255–259 (2003).
Pasqualucci, L. et al. Nature 412, 341–346 (2001).
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Dominguez-Sola, D., Dalla-Favera, R. PINning down the c-Myc oncoprotein. Nat Cell Biol 6, 288–289 (2004). https://doi.org/10.1038/ncb0404-288
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DOI: https://doi.org/10.1038/ncb0404-288
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