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Directing NGF's actions: it's a Rap

Nature Cell Biology volume 7, pages 338–339 (2005)Cite this article

Epidermal growth factor and nerve growth factor (NGF) lead to significantly different temporal patterns of extracellular-signal-regulated kinase activation, and differential regulation of Ras and Rap1 have been implicated in mediating this temporal specificity. Now Sasagawa et al. derive a computational model that incorporates the known signalling interactions and identifies key points of regulation that control these processes.

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Figure 1: EGF and NGF lead to different kinetics of ERK activation.
Figure 2: The computational model takes into account many protein interactions, some of which are shown here.

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  1. the Oregon Health Sciences University, Vollum Institute L-474, 3181 SW Sam Jackson Park Road, Portland, 97201-3098, OR, USA

    Philip J. S. Stork

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Stork, P. Directing NGF's actions: it's a Rap. Nat Cell Biol 7, 338–339 (2005). https://doi.org/10.1038/ncb0405-338

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