Abstract
Ezrin/radixin/moesin (ERM) proteins form crosslinks between cortical actin filaments and the plasma membrane. New findings indicate that they may also bind to the tumour-suppressor protein hamartin, thereby regulating Rho GTPases, the actin-based cytoskeleton and cell adhesion. Loss of hamartin function disrupts cell adhesion, which may contribute to the formation of tumours in individuals carrying hamartin mutations.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gomez, M. R. in Tuberous Sclerosis (Raven, New York, 1988).
Povey, S. et al. Ann. Hum. Genet. 58, 107– 127 (1994).
van Slegtenhorst, M. et al. Science 277, 805–808 (1997).
Xiao, G. H., Shoarinejad, F., Jin, F., Golemis, E. A. & Yeung, R. S. J. Biol. Chem. 272, 6097– 6100 (1997).
Wienecke, R., Konig, A. & DeClue, J. E. J. Biol. Chem. 270, 16409– 16414 (1995).
Jin, F. et al. Proc. Natl Acad. Sci. USA 93, 9154– 9159 (1996).
Ito, N. & Rubin, G. M. Cell 96, 529–539 (1999).
Lamb, R. F. et al. Nature Cell Biol. 2, 281– 287 (2000).
Bretscher, A. Curr. Opin. Cell Biol. 11, 109–116 (1999).
Mangeat, P., Roy, C. & Martin, M. Trends Cell Biol. 9, 187–192 (1999).
Tsukita, S. & Yonemura, S. J. Biol. Chem. 274, 34507–34510 (1999).
Liao, J. C., Berg, L. J. & Jay, D. G. Photochem. Photobiol. 62, 923 –929 (1995).
Matsui, T. et al. J. Cell Biol. 140, 647– 657 (1998).
Hart, M. J. et al. Science 280, 2112– 2114 (1998).
Fukuhara, S., Murga, C., Zohar, M., Igishi, T. & Gutkind, J. S. J. Biol. Chem. 274, 5868– 5879 (1999).
Kourlas, P. J. et al. Proc. Natl Acad. Sci. USA 97, 2145– 2150 (2000).
Hirao, M. et al. J. Cell Biol. 135, 37– 51 (1996).
Matsui, T., Yonemura, S. & Tsukita, S. Curr. Biol. 9, 1259– 1262 (1999).
Takahashi, K. et al. J. Biol. Chem. 272, 23371– 23375 (1997).
Sasaki, T. & Takai, Y. Biochem. Biophys. Res. Commun. 245, 641–645 (1998).
Takahashi, K. et al. Oncogene 16, 3279– 3284 (1998).
Pietromonaco, S. F., Simons, P. C., Altman, A. & Elias, L. J. Biol. Chem. 273, 7594–7603 (1998).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Fukuhara, S., Gutkind, J. A new twist for the tumour suppressor hamartin. Nat Cell Biol 2, E76–E78 (2000). https://doi.org/10.1038/35010506
Issue Date:
DOI: https://doi.org/10.1038/35010506