Fetal haematopoietic stem cells (HSCs) self-renew extensively to build the blood system from scratch. The protein Lin28b negatively regulates the microRNA let-7 to keep levels of its target Hmga2 high, hence conferring high self-renewal potential to fetal HSCs. This regulatory circuit can be experimentally modulated to boost the lower self-renewal activity of quiescent adult HSCs.
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Change history
02 August 2013
In the version of this News and Views originally published, there was an error in Fig. 1: the blue cell on the right should have been labelled ‘Adult HSC’, not ‘Fetal HSC’. This has been corrected in the HTML and PDF versions.
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Pietras, E., Passegué, E. Linking HSCs to their youth. Nat Cell Biol 15, 885–887 (2013). https://doi.org/10.1038/ncb2817
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DOI: https://doi.org/10.1038/ncb2817
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