The lomaiviticins are exceedingly potent antibiotic agents, but the mechanism responsible for this activity has so far been unclear. Now, efficient generation of double-strand breaks in DNA by lomaiviticin A has been linked to the remarkable cytotoxicity of these diazobenzofluorene-containg natural products.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gates, K. S. in Comprehensive Natural Products Chemistry Vol. 7 (ed. Kool, E. T.) 491–552 (Pergamon, 1999).
Newman, D. J. & Cragg, G. M. J. Nat. Prod. 75, 311–335 (2012).
Clardy, J. & Walsh, C. T. Nature 432, 829–837 (2004).
He, H. et al. J. Am. Chem. Soc. 123, 5362–5363 (2001).
Colis, L. C. et al. Nature Chem. 6, 504–510 10.1038/nchem.1944(2014).
Omura, S. et al. Chem. Pharm. Bull. 21, 931–940 (1973).
Gould, S. J., Tamayo, N., Melville, C. R. & Cone, M. C. J. Am. Chem. Soc. 116, 2207–2208 (1994).
Mithani, S., Weeratunga, G., Taylor, N. J. & Dmitrienko, G. I. J. Am. Chem. Soc. 116, 2209–2210 (1994).
Moore, H. W. Science 197, 527–532 (1977).
Nawrat, C. C. & Moody, C. J. Nat. Prod. Res. 28, 1426–1444 (2011).
Fekry, M. et al. J. Am. Chem. Soc. 132, 17641–17651 (2011).
Woo, C. M., Beizer, N. E., Janso, J. E. & Herzon, S. B. J. Am. Chem. Soc. 134, 15285–15288 (2012).
Gates, K. S. Chem. Res. Toxicol. 22, 1747–1760 (2009).
Abeywickrema, A. N. & Beckwith, A. L. J. J. Am. Chem. Soc. 108, 8227–8229 (1986).
Laufer, R. S. & Dmitrienko, G. I. J. Am. Chem. Soc. 124, 1854–1855 (2002).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Gates, K. DNA double whammy. Nature Chem 6, 464–465 (2014). https://doi.org/10.1038/nchem.1965
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchem.1965