Bicyclic peptides that are cell-permeable and can inhibit an intracellular target have been developed. These peptides consist of two rings: one enables the peptide to pass through the membrane, the other can inhibit the target.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer’s disease
Scientific Reports Open Access 17 September 2020
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Lipinski, C. A., Lombardo, F., Dominy, B. W. & Feeney, P. J. Adv. Drug. Del. Rev. 46, 3–26 (2001).
Madani, F., Lindberg, S., Langel, Ü., Futaki, S. & Gräslund, A. J. Biophys. 2011, 414729 (2011).
Jones, A. T. & Sayers, E. J. J. Control. Rel. 161, 582–591 (2012).
Yount, N. Y. & Yeaman, M. R. Annu. Rev. Pharmacol. Toxicol. 52, 337–360 (2012).
Qian, Z. et al. ACS Chem. Biol. 8, 423–431 (2013).
Lian, W., Jiang, B., Qian, Z. & Pei, D. J. Am. Chem. Soc. 136, 9830–9833 (2014).
Heinis, C., Rutherford, T., Freund, S. & Winter, G. Nature Chem. Biol. 5, 502–507 (2009).
van Wandelen, L. T. M. et al. ACS Chem. Biol. 8, 1479–1487 (2013).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Liskamp, R. Bicycling into cells. Nature Chem 6, 855–857 (2014). https://doi.org/10.1038/nchem.2073
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchem.2073