Meropenem/piperacillin/tazobactam is a triple β-lactam combination that kills MRSA in vitro and in a mouse model through a novel synergistic mechanism of action. Similar activity for other carbapenem/β-lactam combinations suggests that MRSA infections might be treatable with combinations of established β-lactams currently classified as ineffective against MRSA.
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K.B. receives retirement compensation from Johnson & Johnson, Pfizer and Bristol-Myers Squibb. She has received research funding from Cubist Pharmaceuticals, Forest Laboratories, AstraZeneca, Tetraphase and Achaogen.
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Bush, K. Synergistic MRSA combinations. Nat Chem Biol 11, 832–833 (2015). https://doi.org/10.1038/nchembio.1935
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DOI: https://doi.org/10.1038/nchembio.1935