Studies have linked the Fucα(1-2)Gal modification of neuronal glycoproteins to cognitive processes such as learning and memory. The identification of synapsins Ia and Ib as the main Fucα(1-2)Gal-bearing neuronal proteins not only suggests previously unknown molecular mechanisms of neuronal plasticity but also indicates the existence of previously unknown glycosylation pathways in neurons.
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Hart, G. Sweet insights into learning and memory. Nat Chem Biol 2, 67–68 (2006). https://doi.org/10.1038/nchembio0206-67
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DOI: https://doi.org/10.1038/nchembio0206-67