The high polyunsaturated fatty acid content of mammalian sperm cell membranes makes them vulnerable to damaging oxidation. A carbohydrate-antioxidant polymer has been developed that greatly increases antioxidant levels in sperm, counteracting any detrimental effects and improving sperm function.
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References
Steenken, S. Chem. Rev. 89, 503–520 (1989).
Aitken, R.J. & Clarkson, J.S. J. Reprod. Fertil. 81, 459–469 (1987).
Fleming, C. et al. Nat. Chem. Biol. 1, 270–274 (2005).
Aust, S.D. in Oxygen Radicals and Tissue Injury (ed. Halliwell, B.) 27–33 (Upjohn Co. and Federation of American Societies for Experimental Biology, Bethesda, Maryland, 1988).
Imlay, J.A. & Linn, S. Science 2=40, 1302–1309 (1988).
Halliwell, B. & Gutteridge, J.M.C. Free Radicals in Biology and Medicine 2nd edn. (Clarendon, Oxford, 1989).
Buettner, G.R. Arch. Biochem. Biophys. 300, 535–543 (1993).
Casini, A.F., Pompella, A. & Comporti, M. Am. J. Pathol. 118, 225–237 (1985).
Donnelly, E.T., McClure, N. & Lewis, S.E.M. Mutagenesis 14, 505–511 (1999).
Kessopoulou, E. et al. Fertil. Steril. 64, 825–831 (1995).
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Donnelly, E. Targeted antioxidant delivery prolongs sperm lifespan. Nat Chem Biol 1, 248–249 (2005). https://doi.org/10.1038/nchembio1005-248
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DOI: https://doi.org/10.1038/nchembio1005-248